Sarah Cai

Bio:
Sarah is a biochemist and structural biologist studying the factors involved in telomere overhang maturation. Her comfort science is protein purification, and she has a love-hate relationship with cryo-EM (but mostly love).

Publications:
S. W. Cai and T. de Lange. (2023) CST-Polα/Primase: the second telomere maintenance machine. Genes Dev Online ahead of print.

S. W. Cai, H. Takai, T. Walz and T. de Lange. (2023) Structural basis of CST–Polα/Primase recruitment and regulation by POT1 at telomeres. bioRxiv 2023.05. 08.539880.

Z. Mirman, S. Cai and T. de Lange (2023) CST/Polα/primase-mediated fill-in synthesis at DSBs. Cell Cycle 22: 379-389.

S.W. Cai, J.C. Zinder, V. Svetlov, M.W. Bush, E. Nudler, T. Walz and T. de Lange (2022) Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state. Nat Struct Mol Biol

L.R. Myler, C.G. Kinzig, N.K. Sasi, G. Zakusilo, S.W. Cai and T. de Lange (2021) The evolution of metazoan shelterin. Genes Dev 35:1625-1641.

D. H. Lin, A. R. Correia*, S. W. Cai*, F.M. Huber, C. A. Jette, and André Hoelz (2018) Structural and functional analysis of mRNA export regulation by the nuclear pore complex. Nat Comm 9: 2319.

Education:
Ph.D. (Rockefeller University, advisor Titia de Lange)

B.S. Chemistry (California Institute of Technology; advisor André Hoelz)

Awards and Fellowships:
Deans' Cup (Caltech)
Merck Index Award (Caltech)
Library Friends' Senior Thesis Prize Award (Caltech)
NSF Graduate Research Fellows Program Fellowship