Sally Dewhurst Publications
S.M. Dewhurst, X. Yao, J. Rosiene, H. Tian, J. Behr, N. Bosco, K.K. Takai, T. de Lange and M. Imieliński (2021) Structural variant evolution after telomere crisis. Nat Commun 12:2093.
K. Hadi et al. (2020) Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs. Cell 183: 197-210.e32.
Isabelle Schmutz Publications
I. Schmutz, A.R. Mensenkamp, K.K. Takai, M. Haadsma, L. Spruijt, R.M. de Voer, S.S. Choo, F.K. Lorbeer, E.J. van Grinsven, D. Hockemeyer, M.C. Jongmans and T. de Lange (2020) TINF2 is a haploinsufficient tumor suppressor that limits telomere length. Elife 9:e61235
I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrity. Nat. Struct. Mol. Biol.: 24:734-742.
I. Schmutz & T. de Lange (2016) Shelterin. Curr Biol. 26: R397-399.
Courtney Lovejoy Publications
C.A. Lovejoy, K. Takai, M.S. Huh, D.J. Picketts & T. de Lange (2020) ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity. PLoS Biol 18: e3000594.
Z. Yang, K.K. Takai, C.A. Lovejoy & T. de Lange (2020) Break-induced replication promotes fragile telomere formation. Genes Dev 34: 1392-1405.
C.A. Lovejoy et al. For the ALT Starr Cancer Consortium. (2012) Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the Alternative Lengthening of Telomeres pathway. PLoS Genetics 8:e1002772
Nazario Bosco Publications
S.M. Dewhurst, X. Yao, J. Rosiene, H. Tian, J. Behr, N. Bosco, K.K. Takai, T. de Lange and M. Imieliński (2021) Structural variant evolution after telomere crisis. Nat Commun 12:2093.
J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis. Cell 163: 1641-1654.
N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465-474.
John Maciejowski Publications
J. Maciejowski, A. Chatzipli, A. Dananberg, K. Chu, E. Toufektchan, L.J. Klimczak, D.A. Gordenin, P.J. Campbell and T. de Lange. (2020) APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis. Nat Genet 52: 884-890.
Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. 15: 1579-1586.
J. Maciejowski & T. de Lange (2017) Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol 18: 175-186.
J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis. Cell 163: 1641-1654.
Francisca Lottersberger Publications
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature: 560: 112-116.
F. Lottersberger, R.A. Karssemeijer, N. Dimitrova, T. de Lange (2015) 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell 163: 880-893.
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.
F. Lottersberger**, A. Bothmer**, D.F. Robbiani, M. Nussenzweig*, T. de Lange* (2013) Role of 53BP1 oligomerization in regulating DSB repair. Proc. Natl. Acad. Sci. USA 110: 2146-2151. **equal contribution. *corresponding author.
Yi Gong Publications
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature: 560: 112-116.
Y. Gong, N. Handa, S.C. Kowalczykowski & T. de Lange (2017) PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev 31: 46-58.
Y. Gong and T. de Lange (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol. Cell 40: 377-387.
Katja Kratz Publications
K. Kratz & T. de Lange (2018) Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b. J Biol Chem: 293: 14384-14392.
F. Erdel, K. Kratz, S. Willcox, J.D. Griffith, E.C. Greene & T. de Lange (2017) Telomere Recognition and Assembly Mechanism of Mammalian Shelterin. Cell Rep 18: 41-53.
Tatsuya Kibe Publications
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature: 560: 112-116.
T. Kibe, M. Zimmermann & T. de Lange (2016) TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell 61: 236-246
M. Zimmermann, T. Kibe, S. Kabir, T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.
T. Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol. Cell. Biol. 30: 1059-1066.
W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2008) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29:471-82.
Ylli Doksani Publications
Y. Doksani & T. de Lange (2016) Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. Cell Rep. 17: 1646-1656.
Y. Doksani, and T de Lange (2014) The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harb. Perspect. Biol. 2014 6: 1-15
Y. Doksani*, J.Y. Wu*, T. de Lange, X. Zhuang (2013) Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-Loop Formation. Cell 155: 345-356. *equal contribution
David Frescas Publications
D. Frescas, and T. de Lange (2014) Binding of TPP1 to TIN2 is required for POT1a,b-mediated telomere protection. J Biol Chem 289: 24180-24187.
D. Frescas, and T. de Lange (2014) TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1. Mol Cell Biol 34: 1349-1362.
D. Frescas and T. de Lange (2014) A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes Dev. 28: 153-166.
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.
Agnel Sfeir Publications
A.S. Tong, J.L. Stern, A. Sfeir, M. Kartawinata, T. de Lange, X.-D. Zhu, T.M. Bryan (2015) ATM and ATR signaling regulate the recruitment of telomerase to telomeres. Cell Reports 13: 1633- 1646
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.
A. Sfeir and T. de Lange (2012) Removal of shelterin reveals the telomere end-protection problem. Science 336: 593-597.H. Scherthan, A. Sfeir, and T. de Lange (2011) Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma 120: 151-157.
S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.
A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.
A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.
D. Hockemeyer, A. J. Sfeir, J.W. Shay, W.E. Wright, and T. de Lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.
Eros Lazzerini Denchi Publications
T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.
E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448:1068-71.
E. Lazzerini Denchi, G.B. Celli and T. de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes and Development 20: 2648-2653.
G.B. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol. 8: 855-862.
Akimitsu Konishi Publications
A. Konishi and T. de Lange (2008) Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA binding domain of TRF2. Genes Dev. 22:1221-30.
Sean Rooney Publications
P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 606-617.
Sara Buonomo Publications
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.
S. Buonomo, Y. Wu, D. Ferguson, T. de Lange (2009) Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J. Cell Biol. 187:385-398.
J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.
Diego Loayza Publications
J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krut chinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279: 47264-47271.
J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.
Loayza and T. de Lange (2004) Telomerase regulation at the telomere: a binary switch. Cell 117: 279-280.
D. Loayza, H. Parsons, J. R. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J. Biol. Chem. 279: 13241-13248.
D. Loayza and T. de Lange (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature, 423: 1013-1018.
Giulia Celli Publications
A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.
E. Lazzerini Denchi, G.B. Celli and T. de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes and Development 20: 2648-2653.
G.B. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol. 8: 855-862.
G. Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2. Nature Cell Biol. 7: 712-718.
Jeffrey Ye Publications
D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8:754-61.
J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krut chinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279: 47264-47271.
J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.
J. Z.-S. Ye and T. de Lange (2004) TIN2 is a tankyrase 1 PARP-modulator in the TRF1 telomere length control complex. Nat. Genet. 36: 618-623.
Jacqueline Jacobs Publications
J.J.L. Jacobs and T. de Lange (2005) p16INK4as a second effector of the telomere damage response. Cell Cycle 4: 1364-1368.
J.J.L. Jacobs and T. de Lange (2004) Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr. Biol. 14: 1-20.
Xu-Dong Zhu Publications
A.S. Tong, J.L. Stern, A. Sfeir, M. Kartawinata, T. de Lange, X.-D. Zhu, T.M. Bryan (2015) ATM and ATR signaling regulate the recruitment of telomerase to telomeres. Cell Reports 13: 1633- 1646
X.-D. Zhu, L. Niedernhofer, B. Kuster, M. Mann, J. H. J. Hoeijmakers, and T. de Lange (2003) ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA containing double minute chromosomes. Mol Cell 6: 1489-1498.
X.-D. Zhu, B. Kuster, M. Mann, J.H.J. Petrini, and T. de Lange (2000) Cell cycle regulated association of the Rad50/Mre11/Nbs1 complex with TRF2 and human telomeres. Nature Genetics 25: 347-352.
L. Zhu, S. Smith, T. de Lange, M. F. Seldin. (1999) Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics 57:320-321.
Jan Karlseder Publications
A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.
J. Karlseder, K. Hoke, O. Mirzoeva, C. Bakkenist, M. Kastan, J.H.J. Petrini, and T. de Lange (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biology 2: 1150-1157.
J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.
A. Smogorzewska, J. Karlseder, A. Jauch, and T. de Lange (2002) DNA ligase IV dependent NHEJ of deprotected human telomeres in G1 and G2. Curr. Biol. 12: 1634-1644.
J Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449.
J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
Bibo Li Publications
B. Li and T. de Lange (2003) Rap1 affects the length and heterogeneity of human telomeres. Mol. Biol. Cell 14: 5060-5068.
S. Hanaoka, A. Nagadoi, S. Yoshimura, S. Aimoto, B. Li, T. de Lange, Y. Nishimura (2001) NMR structure of the hRap1 Myb motif reveals a canonical three helix bundle lacking the positive surface charge typical of Myb DNA binding domains. J. Mol. Biol. 312: 167-175.
H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hulten, T. Lock, and T. de Lange (2000). Mammalian meiotic telomeres: protein composition and their redistribution in relation to nuclear pores. Mol. Biol. Cell 11: 4189-4203.
B. Li, S. Oestreich, and T. de Lange (2000) Identification of Human Rap1: Implications for Telomere Evolution. Cell 101: 471-483.
Susan Smith Publications
H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hulten, T. Lock, and T. de Lange (2000). Mammalian meiotic telomeres: protein composition and their redistribution in relation to nuclear pores. Mol. Biol. Cell 11: 4189-4203.
S. Smith and T. de Lange (2000) Tankyrase promotes telomere elongation in human cells. Current Biol. 10: 1299-1302.
L. Zhu, S. Smith, T. de Lange, M. F. Seldin. (1999) Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics 57:320-321.
S. Smith, T. de Lange (1999) Cell cycle dependent localization of tankyrase, a telomeric PARP, to centrosomes and nuclear pore complexes. J. Cell Sci. 112: 3649-3656.
S. Smith, I. Giriat, A. Schmitt, T. de Lange (1998) Tankyrase, a poly(ADP-ribose)polymerase at human telomeres. Science 282: 1484-1488.
S. Smith and T. de Lange (1997) TRF1, a mammalian telomeric protein. TIG 13: 21-26.
A. Bianchi, S. Smith, L. Chong, P. Elias, T. de Lange (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J. 7: 1785-1794.
Dominique Broccoli Publications
J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
D. Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics 17: 231-235.
D. Broccoli, L. Chong, S. Oelmann, A.A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M.M. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. Human Mol. Genet. 6: 69-76.
D. Broccoli, L.A. Godley, L.A. Donehower, H.E. Varmus, T. de Lange (1996) Telomerase activation in mouse mammary tumors: lack of telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol. Cell. Biol. 16: 3765-3772.
L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.
D. Broccoli, J.W. Young, T. de Lange (1995) Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92: 9082-9086.
Bas van Steensel Publications
Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000). Control of human telomere length by TRF1 and TRF2. Mol. Cell Biol. 20: 1659-1668.
B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.
B. van Steensel and T. de Lange (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-744.
D. Broccoli, L. Chong, S. Oelmann, A.A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M.M. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. Human Mol. Genet. 6: 69-76.
M.E.E. Luderus, B. van Steensel, L. Chong, O.C.M. Sibon, F.F.M. Cremers, T. de Lange (1996) Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J. Cell Biol. 135: 867-883.
L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.
Eva Luderus Publications
M.E.E. Luderus, B. van Steensel, L. Chong, O.C.M. Sibon, F.F.M. Cremers, T. de Lange (1996) Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J. Cell Biol. 135: 867-883.
John Hanish Publications
L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.
J.P. Hanish, J. Yanowitz, T. de Lange (1994) Stringent sequence requirements for telomere formation in human cells. Proc. Natl. Acad. Sci. USA 91: 8861-8865.
Maria Cardenas-Corona Publications
M.E. Cardenas, A. Bianchi, T. de Lange (1993) A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. Genes and Development 7: 883-894.
Zhe Yang’s Publications
Z. Yang, K. Sharma and T. de Lange (2022) TRF1 uses a noncanonical function of TFIIH to promote telomere replication. Genes Dev 36: Online ahead of print
Z. Yang, K.K. Takai, C.A. Lovejoy & T. de Lange (2020) Break-induced replication promotes fragile telomere formation. Genes Dev 34: 1392-1405.
Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. 15: 1579-1586.
Zachary Mirman Publications
Z. Mirman, S. Cai and T. de Lange (2022) CST/Polα/primase-mediated fill-in synthesis at DSBs. Cell Cycle 1-11.
Z. Mirman, K. Sharma, T.S. Carroll and T. de Lange (2022) Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4(WDR70). DNA Repair (Amst) 113:103320.
Z. Mirman, N.K. Sasi, A. King, J.R. Chapman and T. de Lange (2022). 53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis. Nat Cell Biol 24, 51–61
Z. Mirman & T. de Lange (2020) 53BP1: a DSB escort. Genes Dev. 34: 7-23.
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature: 560: 112-116.
Leonid Timashev Publications
L.A. Timashev & T. de Lange (2020) Characterization of t-loop formation by TRF2. Nucleus 11: 164-177.
L.A. Timashev, H. Babcock, X. Zhuang & T. de Lange (2017) The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev 31: 578-589.
I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrity. Nat. Struct. Mol. Biol.: 24:734-742.
Roos Anna Karssemeijer Publications
F. Lottersberger, R.A. Karssemeijer, N. Dimitrova, T. de Lange (2015) 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell 163: 880-893.
Shaheen Kabir Publications
H. Takai, E. Jenkinson, S. Kabir, R. Babul-Hirji, N. Najm-Tehrani, D.A. Chitayat, Y.J. Crow & T. de Lange (2016) A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes Dev 30: 812-826.
S. Kabir, D. Hockemeyer, T. de Lange (2014). TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation. Cell Rep 9:1273-1280
M. Zimmermann, T. Kibe, S. Kabir, T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.
S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.
A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.
Michal Zimmerman Publications
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature: 560: 112-116.
T. Kibe, M. Zimmermann & T. de Lange (2016) TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell 61: 236-246
M. Zimmermann, T. Kibe, S. Kabir, T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.
M. Zimmermann, and T. de Lange (2014) 53BP1: pro choice in DNA repair. Trends Cell Biol 24: 108-117.
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.
Teresa Davoli Publications
T. Davoli and T. de Lange (2012) Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation in mouse cells. Cancer Cell 21: 765-776.
T. Davoli & T. de Lange (2011) The Causes and Consequences of Polypolidy in Normal Development and Cancer. Annu. Rev. Cell Dev. Biol, 27: 585-610
T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.
Peng Wu Publications
Y. Doksani*, J.Y. Wu*, T. de Lange, X. Zhuang (2013) Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-Loop Formation. Cell 155: 345-356. *equal contribution
P. Wu, H. Takai and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.
P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 606-617.
P. Wu & T . de Lange (2009) Human telomerase caught in the act. Cell 138: 432-434.
S. Buonomo, Y. Wu, D. Ferguson, T. de Lange (2009) Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J. Cell Biol. 187:385-398.
P. Wu and T. de Lange (2008) No Overt Nucleosome Eviction at Deprotected Telomeres. Mol. Cell Biol. 28:5724-35.
Megan van Overbeek Publications
P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 606-617.
A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.
Y. Chen, Y. Yang, M. van Overbeek, J. R. Donigian, P. Baciu, T. de Lange, and M. Lei (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-6.
M. van Overbeek and T. de Lange (2006) Apollo, an Artemis related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr. Biol.16: 1295-1302.
J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krut chinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279: 47264-47271.
Nadya Dimitrova
F. Lottersberger, R.A. Karssemeijer, N. Dimitrova, T. de Lange (2015) 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell 163: 880-893.
N. Dimitrova & T. de Lange (2009) Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of NHEJ in G1 and resection-mediated inhibition of NHEJ in G2. Mol. Cell. Biol. 290:5552-5563.
N. Dimitrova, YC. Chen, DL. Spector, T. de Lange (2008) 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature.456:524-8.
N. Dimitrova and T. de Lange (2006) MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes and Development. 20: 3238-3243.
Jill Donigian Publications
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.
Y. Chen, Y. Yang, M. van Overbeek, J. R. Donigian, P. Baciu, T. de Lange, and M. Lei (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-6.
J. R. Donigian and T. de Lange (2007) The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the Shelterin Complex. J. Biol. Chem. 282:22662-7.
J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krut chinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279: 47264-47271.
D. Loayza, H. Parsons, J. R. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J. Biol. Chem. 279: 13241-13248.
Dirk Hockemeyer Publications
I. Schmutz, A.R. Mensenkamp, K.K. Takai, M. Haadsma, L. Spruijt, R.M. de Voer, S.S. Choo, F.K. Lorbeer, E.J. van Grinsven, D. Hockemeyer, M.C. Jongmans and T. de Lange (2020) TINF2 is a haploinsufficient tumor suppressor that limits telomere length. Elife 9:e61235
S. Kabir, D. Hockemeyer, T. de Lange (2014). TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation. Cell Rep 9:1273-1280
A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.
W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2008) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29:471-82.
D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 22:1773-1785.
D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8:754-61.
D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.
D. Hockemeyer, A. J. Sfeir, J.W. Shay, W.E. Wright, and T. de Lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.
J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.
Kristina Hoke Publications
J. Karlseder, K. Hoke, O. Mirzoeva, C. Bakkenist, M. Kastan, J.H.J. Petrini, and T. de Lange (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biology 2: 1150-1157.
D. Loayza, H. Parsons, J. R. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J. Biol. Chem. 279: 13241-13248.
Richard Wang Publications
D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 22:1773-1785.
H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.
R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.
X. Dong, M.A. Michelis, J. Wang, R. Bose, T. de Lange, W.H. Reeves (1998) Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. Arthritis Rheum. 41:1505-1510.
Joshua Silverman Publications
J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.
Agata Smogorzewksa Publications
R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.
A. Smogorzewska and T. de Lange (2004) Regulation of telomerase by telomeric proteins. Ann. Rev. Biochem. 73: 177-208.
H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556.
A. Smogorzewska, J. Karlseder, A. Jauch, and T. de Lange (2002) DNA ligase IV dependent NHEJ of deprotected human telomeres in G1 and G2. Curr. Biol. 12: 1634-1644.
A. Smogorzewska and T. de Lange (2002). Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21: 4338-4348.
J Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449.
A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000). Control of human telomere length by TRF1 and TRF2. Mol. Cell Biol. 20: 1659-1668.
B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.
D. Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics 17: 231-235.
Alessandro Bianchi Publications
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature: 560: 112-116.
A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000). Control of human telomere length by TRF1 and TRF2. Mol. Cell Biol. 20: 1659-1668.
J. D. Griffith, L. Comeau, S. Rosenfield, R. Stansel, A. Bianchi, H. Moss, T. de Lange. (1999) Mammalian telomeres end in a large duplex loop. Cell 97: 503-514.
A. Bianchi and T. de Lange (1999) Ku binds telomeric DNA in vitro. J. Biol. Chem. 274: 21223-21227.
A. Bianchi, R. M. Stansel, L. Fairall, J. D. Griffith, D. Rhodes, T. de Lange (1999) TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J. 18: 5735-5744.
J. Griffith, A. Bianchi, T. de Lange (1998) TRF1 promotes parallel pairing of telomeric DNA in vitro. J. Mol. Biol. 278: 79-88.
A. Bianchi, S. Smith, L. Chong, P. Elias, T. de Lange (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J. 7: 1785-1794.
M.E. Cardenas, A. Bianchi, T. de Lange (1993) A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. Genes and Development 7: 883-894.
Henrik Tommerup Publications
H. Tommerup, A. Dousmanis, T. de Lange (1994) Unusual chromatin in human telomeres. Mol. Cell. Biol. 14: 5777-5785.