The following genetically altered mouse embryonic fibroblast cells (MEFs) are available from ATCC:

TRF1 flox

A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.

ATCC URL: https://www.atcc.org/Products/All/CRL-3316

ATCC number: CRL-3316

TRF2 flox

G. Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2. Nature Cell Biol. 7: 712-718.

ATCC URL: https://www.atcc.org/Products/All/CRL-3317

ATCC number: CRL-3317

Rap1 flox

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

ATCC URL: https://www.atcc.org/Products/All/CRL-3319

ATCC number: CRL-3319

TIN2 flox

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

ATCC URL: https://www.atcc.org/Products/All/CRL-3318

ATCC number: CRL-3318

TPP1 flox

T. Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol. Cell. Biol. 30: 1059-1066.

ATCC URL: https://www.atcc.org/Products/All/CRL-3320

ATCC number: CRL-3320

POT1a flox

Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

ATCC URL: https://www.atcc.org/Products/All/CRL-3321

ATCC number: CRL-3321

POT1b flox

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

ATCC URL: https://www.atcc.org/Products/All/CRL-3322

ATCC number: CRL-3322

POT1a/b flox

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

ATCC URL: https://www.atcc.org/Products/All/CRL-3323

ATCC number: CRL-3323

Tel2 flox

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

ATCC URL: https://www.atcc.org/Products/All/CRL-3324

ATCC number:  CRL-3324